Regulatory T cells

Regulatory T cells (Tregs) are a subpopulation of lymphocytes that have been found to be essential in maintaining peripheral tolerance, preventing autoimmune diseases and limiting the extent of inflammatory disorders. Tregs migrate throughout the body to sites of inflammation to dampen and suppress the inflammatory process.

One of the primary mechanisms by which Tregs exert their effects is through the secretion of anti-inflammatory cytokines, especially IL-10. We have found that ZPS therapeutics result in increased production of anti-inflammatory IL-10 by Tregs, specifically at sites of inflammation. As there are exceedingly few molecules reported to date that can increase Treg number and activity, our company’s development of ZPS therapeutics opens up an entirely new approach to treating diseases in which Treg activity is essential.