TREG modulation to treat immune-mediated diseases

Modulating regulatory T cells (TREGs) to treat immune-mediated disease

Symbiotix Biotherapies, Inc. is a pioneering immunomodulation company that is developing a novel class of molecular therapeutics derived from the human microbiome that enhance regulatory T cells (TREGs) at sites of inflammation. Emerging from over a decade of research at Brigham & Women’s Hospital/Harvard Medical School, California Institute of Technology and Dartmouth College by our company’s scientific founders, distinguished thought leaders in the microbiome field, Symbiotix is rapidly moving forward translational activities to bring to market Reglemers™, first-in-class molecules that modulate the activity of regulatory T cells. Our lead program is based on the first molecule to emerge from the human microbiome, and is a first-in-class oral agent for the treatment of serious immune-mediated diseases.

Regulatory T Cells

We have found that Reglemers™ increase TREG production of protective cytokines at sites of inflammation.

Learn more about how this opens up an entirely new approach to treating diseases »


Over the past few years, a new paradigm has emerged of how symbiotic microbes interact with the human immune system.

Learn how our approach is developing novel molecular therapeutics from the microbiome »


We have found important new biology and a fundamentally novel anti- inflammatory mechanism.

Learn how we are advancing development efforts on Reglemers™ »